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Medical Guide for Ayahuasca Retreat, What mediction is dangerous with Ayahuasca

A full and coherent guide to medications that can negatively interact with Ayahuasca and why. We list what medications are dangerous to take with Ayahuasca and what you can take. If you are planning an Ayahuasca retreat in Peru we always advise to seek medical advice of a trained physician should you have any doubts. To stay safe on an Ayahuasca Retreat please be sure to check what medications you can take. Be sure to chose a Safe and Authentic Ayahuasca Retreat like Shakruna Ayahuasca Retreats


Shakruna Ayahuasca Retreat Guidelines

Before you read this, I ask you to forgive me if the tone sounds in any way harsh, this document is serious and this is because you life and well being is very serious to us all, we love you!

 Dearest friends, we are so glad you are hear to sit and learn with Maestro Leonardo and Maestra Lucia but before you do so it is ESSENTIAL that you have read and responded with truth to our STRICT RULES about what you can and cannot do in this space regarding your intake of FOOD and MEDICATIONS during your stay.

This document is not a guideline, this is not flexible in anyway and is here for YOUR SAFETY and we ask you once reading this to sign a disclaimer stating you have read, understood and will adhere to these rules of practice whilst staying on site.


Ayahuasca is a wonderful teacher and extraordinary guide but she is a plant of the earth and she only works fully and safely in the right energetic environment. If you combine Ayahuasca with the WRONG things then it can seriously affect your journey and MAY KILL YOU.

The Shamanic Family nor Shakruna Ayahuasca Retreats take any responsibility for you choosing to NOT read our advice. So please, dear friends, listen up.

There are a huge range of medications that are not safe to use with Ayahuasca to varying degrees and all have a different amount of time that they take to leave the body to leave you clean and safe to drink Ayahuasca here.

Our clear and simple rule is :

“You cannot take ANY medications AT ALL while drinking here”

In addition if you have taken any medications in the last year, YOU are responsible to consult with you doctor as to if you are safe to drink Ayahuasca and if you regularly intake medications to manage your well being YOU are NOT to quit them in order to be here WITHOUT the consultation and advice of YOUR DOCTOR. If you decided in conjunction with your doctor to cease the intake of your medication you must follow his advice on how long it takes for your medication to fully leave your system leaving no trace in the body that may interact with Ayahuasca.

We take no responsibility for your choice to not read and follow this advice nor if you are not able to understand the clear advice we will now present to you.

We will now provide you with a list of medications that you cannot use with Ayahuasca, simply put this includes:

All pharmaceutical drugs (this includes all over the counter medications such as allergy meds and asthma meds)

All recreational drugs

All herbal remedies, herbs and vitamins not included on the list of food you can eat while here


A Complex list of Medications and herbs NOT to use while here

Below is a list of SOME medical conditions, pharmaceuticals and supplements that are not compatible with drinking Ayahuasca. Please speak to your doctor if your condition is not listed.

 We highly recommend all guests get a full medical checkup prior to visiting the Shamanic Family, including an ECG to screen for any heart function abnormalities as these can be undetected until you test for it.  

Medical conditions not suitable for treatment with Ayahuasca.


Bipolar disorder

Other dissociative conditions including antisocial, suicidal tendencies and mood disorders 

Serious heart conditions

Pharmaceuticals and Supplements not to be mixed with Ayahuasca

We require all guests to refrain from taking any pharmaceuticals or supplements during their stay. Some medications need to be stopped well in advance (at least 1 month and sometimes up to 6 months) of drinking Ayahuasca. Different substances require longer to clear from your system so please consult your doctor to establish how long you need to stop taking them before visiting the Shamanic Family and what the side effects may be when you do so. 

These are some of the medications particularly contra-indicative with ayahuasca. 

 SSRI’s (any selective serotonin reuptake inhibitor)

amphetamines (meth-, dex-, amphetamine)

antihypertensives (high blood pressure medicine)

appetite suppressants (diet pills)

medicine for asthma, bronchitis, or other breathing problems

antihistamines, medicines for colds, sinus problems, hay fever, or allergies (Actifed DM, Benadryl, Benylin, Chlor-Trimeton, Compoz, etc.)

CNS (central nervous system) depressants



Specific drugs that should not be combined with Ayahuasca:


Amantadine hydrochloride (Symmetrel)

Amoxapine (Asendin)



Bupropion (Wellbutrin)

Buspirone (BuSpar)

Carbamazepine (Tegretol, Epitol)


Clomipramine (Anafranil)


Cyclobenzaprine (Flexeril)

Cyclizine (Marezine)

Desipramine (Pertofrane)

Dextromethorphan (DXM)

Disopyramide (Norpace)

Doxepin (Sinequan)


Flavoxate Hydrochloride (Urispas)

Fluoxetine (Prozac)

Imipramine (Tofranil)

Isocarboxazid (Marplan)

Levodopa (Dopar, Larodopa)

Loratadine (Claritin)

Maprotiline (Ludiomil)

Meperidine (Demerol)

Methylphenidate (Ritalin)

Nortriptyline (Aventyl)

Oxybutynin chloride (Ditropan)

Orphenadrine (Norflex)


Paroxetine (Paxil)


Phenelzine (Nardil)

Procainamide (Pronestyl)

Protriptyline (Vivactil)


Quinidine (Quinidex)



Selegiline (Eldepryl)

Sertraline (Zoloft)



Tranylcypromine (Parnate)

Tricyclic antidepressants (Amitriptyline, Elavil)

Trimipramine (Surmontil)



Herbs and supplements not compatible 

St. Johns Wort






Thank you for taking the time to read and understand this information. Please now sign your personal disclaimer to say that you are 100% responsible for your actions and conduct whilst staying with the Shamanic Family.